منابع مشابه
Further Observations on Use of D-penicillamine in Cystinuria.
It was shown in a previous communication (Crawhall et al., 1963) that the abnormally high level of cystine excretion found in homozygotes for cystinuria could be reduced for short periods by the administration of D-penicillamine. This paper reports the results of administering the drug continuously to a group of cystinuric patients for periods of five months to one year. We have used the D-isom...
متن کاملUse of D-Penicillamine in the Neonatal Hyperbilirubinemias
It appears that bilirubin IXᾰ has unique structural properties which might have been predicted on the basis of modern concepts of organic chemistry but whose biological implications certainly were not fully appreciated [1]. The initial breakdown product of haemoglobin is UCB (unconjegated or indirect bilirubin) which is insoluble in water but soluble in lipids. This process is catalyzed by an i...
متن کاملHepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.
Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine. Both recovered after withdrawal of the drug. These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.
متن کاملD-penicillamine in rheumatoid arthritis.
D-penicillamine (D-pen) has gained wide-spread use as a potent suppressor of disease activity in rheumatoid arthritis (RA) and juvenile chronic arthritis (JCA). The drug has been established for antirheumatotd therapy on the basis o f a considerable number o f comparative clinical studies o f D-pen treatment versus placebo or other disease modifying antirheumatic drugs (DMARDs). Despite the pos...
متن کامل[D-penicillamine in rheumatoid arthritis].
In view of the claim that alclofenac has a specific antirheumatoid action a detailed biochemical study has been made over a 6-month period of 2 groups of patients with rheumatoid arthritis receiving either alclofenac or D-penicillamine for the first time. We found no biochemical evidence and little clinical evidence that alclofenac had a 'penicillamine-like' effect in rheumatoid arthritis.
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1985
ISSN: 0003-4967
DOI: 10.1136/ard.44.4.284